The Six Nations was a province in the North American Union. It was largely made up of the Iroquois Confederacy which controlled the land just west of New York Province, and did so for the most part under their own laws. Along with bordering New York, The Six Nations was bordered by Pennsylvania to the south and Canada to the west. The North American Union had charge of their dealings with foreign powers.

Thomas Bushell and Samuel Stanley traveled to the Six Nations in pursuit of The Two Georges, which had been stolen by the Sons of Liberty.

Doshoweh was the capital and largest city of the province.