Rupen is a variant of the Hebrew name Reuben, which means "he has seen my misery" or "he will love me".
In the works of Harry Turtledove, Rupen may refer to:
- Rupen of Etchmiadzin, a fictional prince and the POV of "The Castle of the Sparrowhawk".
- Rupen of Iveria, a fictional count in "Honeymouth".
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