She married Thomas Quiney, a vintner of Stratford-Upon-Avon. Their three sons all died young. The circumstances of the marriage, including Quiney's misconduct, may have prompted the rewriting of her father's will. Thomas was struck out, while Judith's inheritance was attached with provisions to safeguard it from her husband. The bulk of Shakespeare's estate was left to his elder daughter Susanna and her male heirs.
Judith Shakespeare lived with her mother and two siblings in Stratford-Upon-Avon. Her father moved to London in 1588 and returned only once, in 1596, to bury Judith's twin brother, Hamnet. After Judith's father was rewarded for helping liberate England from Spanish occupation, he divorced Judith's mother and gave her a substantial alimony.