Hernando de Talavera (1428 - 14 May 1507) was a prominent political and religious figure in Spain during the period of the country's unification and expulsion of Muslim rule. He was Queen Isabella I of Castile's confessor, and eventually rose to the office of Archbishop of Granada. He appears to have been descended from Jewish converts, a fact which was used against him in his twilight years by rivals in the Spanish Inquisition. He was imprisoned in 1505, the year following Isabella's death, until Pope Julius II ordered his release. He died in 1507.
It has been speculated that Talavera was part of the committee that initially rejected Christopher Columbus' proposal to reach Asia by sailing west.
Fray Hernando de Talavera headed the first committee of learned men and mariners appointed by King Fernando and Queen Isabella to examine the feasibility of Cristóbal Colón's proposal to reach the Indies by sailing west. This committee rejected the plan.